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ASCR Discovery carries original articles about computational science from the research portfolio of the Office of Advanced Scientific Computing Research in the Department of Energy Office of Science, plus links to DOE science highlights and other computational science-related content. ASCR-supported research includes projects at DOE national laboratories, at many public and private universities and collaborations with other agencies and institutions.
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Supercomputer simulations predict how E. coli adapts to environmental stresses.
Warmer temperatures can alter a cell’s protein structure. Researchers developed a systems-level computational model, FoldME, that can accurately predict how E. coli responds to temperature changes and genetic mutations. FoldME could aid in designing engineered organisms useful in biofuel production and patient-specific treatments for bacterial infections.