March 2018

The Secret Lives of Cells

Supercomputer simulations predict how E. coli adapts to environmental stresses.

Warmer temperatures can alter a cell’s protein structure. Researchers developed a systems-level computational model, FoldME, that can accurately predict how E. coli responds to temperature changes and genetic mutations. FoldME could aid in designing engineered organisms useful in biofuel production and patient-specific treatments for bacterial infections.